The very plausible third way...!

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Jayabalan Joseph Jan. 9, 2018, 12:55 a.m. PST
Non-Darwinists all through the past century have encountered strict opposition; when trying to introduce new concepts related to 'Evolution which is driven by Large Mutational changes'...

This includes concepts like Saltationism, Mutationism, Hopeful Monster Hypothesis or James Shapiro's third way...

When ever these concepts were introduced, Darwinist were quick to point their fingures at "Mutational Load", which as per theory could potentially harm a cell when multiple new mutations are introduced...

But it is an established Fact that cells (organisms) have survived and even thrived after large mutational events. The 2R genome duplication event is one such an event in Evolutionary history (seen from thr many genome sequences), which clearly proves that the Darwinian claims are absolutely baseless...

From a molecular perspective, I believe that there is a good reason to support the third way of evolution... Because as observed in humans, we humans have duplicate copies of the 23 somatic chromosomes and so duplicate copies of all their genes as well... But it is known that just one of those two gene copies is active 'at any give time'. The other gene pair is normaly repressed by means of 'trans-acting repressor proteins' that bind to its promoter region... It doesn't matter if there are two or even more copies of a given gene, generated by the action of transposans or due to defects in chromosomal duplication during cell division or by other means; the repessor molecules would still bind to their promotors, there by repressing them all...

It is these repressed gene copies (that are taken offline for improvement), which would undergo active mutations. If the mutations would result in a more effecient gene product; then this gene would automatically over take the other copy and would dominate, by producing its own repressors... And the other copy would go offline... This is natural selection (survival game) happening at the base level, and happening in between the copies of a given gene...! There by genes getting constantly improved and so the organism responding better to its surrounding...

Ref: https://www.semanticscholar.org/paper/Wanda-a-database-of-duplicated-fish-genes-Peer-Shawe-Taylor/33898a4d696a8e095ca17e6ce64e33158b167477

Wishes,
Joseph J

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Jayabalan Joseph Jan. 9, 2018, 2:45 a.m. PST
Additions:

...It is these repressed gene copies (that are taken offline for improvement), which would attract active mutations... While the active copy of the gene is functional and so does not under go any mutation. Hence the cell keep functioning normally using the active gene copy... By this way 'Mutational Load' never seems to affect a cell in a big way...!

PS: It looks like the 'proof reading' and other 'DNA repair' mechanisms of the cell are very capable of distinguishing between an active functing gene, and a dormant copy of that gene which has been switched off for maintainance (mutation)...!!!

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Magdy Taher Jan. 11, 2018, 10:07 a.m. PST
lah bialwarathat.[1]
alnuwkiliutidat hi aljaziyat al'asasiat alsaghirat lil'ahmad alnawawiat , watastatie tarkib jaziyaat kabiratin. tutabie jazayyaat sukr 'uhadi wa'iistar hamd alfsfwryk fi silsilati, bihayth yartabit bikuli jazi' sakar ahd alqawaeid alnawawiati. bilayin alqawaeid alnawawiat tushakil bilayin alnuwkiliawtadiat alty tataras fi altarkib allawalbii almuzdawij almusamaa aldna.
tastatie al'ahmad alnawawiat takwin birutinat, wakarbuhidrat walibid (shhamayata). kama 'anaha hi alty tkwwn alhamd alnawawiu alriybuziu almanqus al'aksajin . hdha aldanaa hu eimad wujud alkayinat alhayat ealaa mukhtalaf 'anwaeiha . fahu yahmil alshafrat alty yatakhalaq minha aljiniun min albuaydat almukhsibati. wahu aldhy yahmil alaikhtilaf bayn albashri, min hayth: aljins (dhkur wa'unthaa) , walshukli, walluwna.
waqad tamakan fi eam 1965 alealman jims watsun wafiransis karik fi muntasaf alqarn al 20 min aiktishaf alshakl alhilzunii lilhamd alnawawii alriybuzii manqus al'aksajin DNA, watabayan 'anah murkab min salasil min al'ahmad alnawawiati. wa'adaa dhlk 'iilaa altaearuf ealaa kayfiat takhzin almaelumat alwarathiati, wahifzaha, wakayfiat naqlaha min jil liakhar.
bijanib wazifat al'ahmad alnawawiat kamakhazin lilmaelumat fi alkayinat alhayat fahi taqum 'aydaan bihaml 'iisharat fi 'aeda' al'ahya'i, wayumkinuha thfyz tufaeulat hayawiat.

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Magdy Taher Jan. 11, 2018, 10:08 a.m. PST
lah bialwarathat.[1]
alnuwkiliutidat hi aljaziyat al'asasiat alsaghirat lil'ahmad alnawawiat , watastatie tarkib jaziyaat kabiratin. tutabie jazayyaat sukr 'uhadi wa'iistar hamd alfsfwryk fi silsilati, bihayth yartabit bikuli jazi' sakar ahd alqawaeid alnawawiati. bilayin alqawaeid alnawawiat tushakil bilayin alnuwkiliawtadiat alty tataras fi altarkib allawalbii almuzdawij almusamaa aldna.
tastatie al'ahmad alnawawiat takwin birutinat, wakarbuhidrat walibid (shhamayata). kama 'anaha hi alty tkwwn alhamd alnawawiu alriybuziu almanqus al'aksajin . hdha aldanaa hu eimad wujud alkayinat alhayat ealaa mukhtalaf 'anwaeiha . fahu yahmil alshafrat alty yatakhalaq minha aljiniun min albuaydat almukhsibati. wahu aldhy yahmil alaikhtilaf bayn albashri, min hayth: aljins (dhkur wa'unthaa) , walshukli, walluwna.
waqad tamakan fi eam 1965 alealman jims watsun wafiransis karik fi muntasaf alqarn al 20 min aiktishaf alshakl alhilzunii lilhamd alnawawii alriybuzii manqus al'aksajin DNA, watabayan 'anah murkab min salasil min al'ahmad alnawawiati. wa'adaa dhlk 'iilaa altaearuf ealaa kayfiat takhzin almaelumat alwarathiati, wahifzaha, wakayfiat naqlaha min jil liakhar.
bijanib wazifat al'ahmad alnawawiat kamakhazin lilmaelumat fi alkayinat alhayat fahi taqum 'aydaan bihaml 'iisharat fi 'aeda' al'ahya'i, wayumkinuha thfyz tufaeulat hayawiat.
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Jayabalan Joseph Jan. 11, 2018, 11:08 a.m. PST
Looks like a auto bot has responded... !!!

I hardly understand anything...!

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concepter Sept. 22, 2018, 10:19 a.m. PDT
Are you right, why do not people try to make themselves understood?
It is as if language were used to create a barrier to ward off, rather than a way to bring minds closer together.

Anyway, what you said is very, very interesting:
there is a part of the cell that does not change that manages its part that must change, then the part that has changed takes the place of the part that had not changed, then the mutation actually takes place.

It is very logical, and it could not be otherwise!
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