I am Director of Pacific Center for Genome Research and a tenured Associate Professor at University of Hawaiʻi Cancer Center, University of Hawaiʻi at Mānoa. I have a broad background in biomedical sciences, with specific training and expertise in genetic epidemiology and cancer epidemiology. My research has focused on applying a multi-disciplinary approach to investigate the influence of genetic and non-genetic factors on the etiology and prognosis of chronic diseases, especially cancer. In ongoing efforts I direct (as PI) large projects in which I organize teams comprising of multiple investigators with interdisplinary expertise and experience, including a large U54 Center grant, a NCI U01 grant, and a NCI R01 grant, with total costs of approximately 18 million dollars. I have over 120 papers, many in highly respected journals, on research involving genetic epidemiological studies and cancer epidemiologic studies. I have accumulated extensive experience of conducting integrative multi-omics studies using genetic instruments to identify candidate genes and biomarkers associated with cancer risk. Specifically, I have led transcriptome-wide association studies (TWAS) and splicing TWAS to identify susceptibility genes and altered splicing for risks of pancreatic, prostate, and other cancers (Liu et al, Cancer Res; Wu et al, Cancer Res; Wu et al Nat Genet). I have conducted proteome-wide association studies of pancreatic cancer (PC) and prostate cancer (PCa) in Europeans using blood protein quantitative trait loci (pQTLs) and protein genetic prediction models as instruments, which identified 54 proteins for PC risk and 39 proteins for PCa risk (Zhu et al, GigaScience; Wu et al, Cancer Res). I have completed methylome-wide association studies of PC and PCa in Europeans using DNA methylation genetic prediction models built in the blood, which identified 45 CpG sites for PC risk and 759 CpG sites for prostate cancer risk (Zhu et al, Cancer Epidemiol Biomarkers Prev; Wu et al, Nat Commun).