“Innovating microgravity models to advance astronaut health and space biomanufacturing.”
Dr. Mandip Sachdeva is a biomedical scientist and innovator with expertise in drug delivery, nanotechnology, exosome engineering, microfluidics, bioreactor systems, and mammalian cell-based models. His research aligns with NASA’s mission to improve ground-based microgravity and partial-gravity simulation platforms, including random positioning machines, 2-D and 3-D clinostats, and rotating wall vessel bioreactors. His NASA-relevant interests include growing stem cells in bioreactors under simulated microgravity, enhancing exosome production through microgravity-inspired culture conditions, and developing organoid models under Earth-based microgravity simulation. Through these approaches, Dr. Sachdeva aims to better understand how altered gravity influences mammalian cell growth, therapeutic cargo production, tissue-like organization, and regenerative potential. His long-term goal is to develop translational bioengineering tools that support astronaut health, space biomanufacturing, and biomedical discoveries benefiting human health on Earth.