My overall research theme is the molecular mechanism of human disease development, blending expertise in medicine, public health, genomics, epigenetics, and advanced toxicology. I have investigated complex host-pathogen interactions, demonstrating how environmental microorganism exposure epigenetically modulates innate immune responses and chronic inflammation susceptibility. As a Principal or Co-Investigator on multiple NIH-funded grants, I have developed innovative single cell-based high-throughput and high-content analysis methods. Specifically, I led the creation of an advanced 3D testicular cell co-culture model and applied machine learning to predict in vivo reproductive toxicity. Currently at Reprotox, I am optimizing the human in vitro mini-testis model for regulatory adoption (NAMs). I have successfully managed projects, budgets, and collaborative teams, maintaining a strong publication record and directly contributing to study design, data analysis, and result interpretation.