Infrastructure Vision 2050 Challenge: Create a system of transportation for the United States that will meet the needs of all users in 2050 and beyond.

Clinical Trials Innovation Prize: Producing a breakthrough that doubles the accrual rate of clinical trials in the diagnosis and treatment of cancer.

LIVES: Leveraging Impactful Videos to End Stigma: Create a 1-3 minute video to reduce the stigma surrounding addiction and inspire those struggling with the disease to seek treatment.

Cognitive Computing Challenge: Build a cognitive system that can read a document, then load a database with what it finds.