My early research works focus on the function of BRCA1 and BRCA2 in breast cancer development and DNA damage repair. BRCA1 and BRCA2 are tumor suppressor proteins. Our studies demonstrated BRCA1 proteins are transported to the nucleus and their tyrosine phosphoproteins are associated with E2F, cyclins and cyclin dependent kinases. Furthermore, we found that BRCA1 interacts with cAMP-response element-binding protein (CREB) binding protein (CBP) in transcriptional regulation through histone acetylation. Lately, we found that BRCA1 and BRCA2 are differentially involved in DNA double strand breaks repair thorough non-homologous end joining and homologous recombination pathways. Our work provides an important mechanism for braking cell proliferation leading to the development of breast and ovarian cancers and for developing breast cancer therapy. My major research interest is to understand the mechanism of DNA double strand break repair. In my research career development as NIH postdoctoral fellowship, I study the mechanism underlying DNA double strands break repair in eukaryote cells. My studies indicated that DNA-PK and ligase IV are involved in non-homologous end joining (NHEJ) in mammalian cells and other unknown components contributes to Ku-independent NHEJ pathway with a slow kinetics. Through biochemical and genetic studies, we first isolated and identified a backup NHEJ pathway including PARP-1, DNA ligase III and histone H1. Recent studies further supported that this alternative NHEJ pathway play a critical role in maintaining genomic stability. Modulation of gene expression in this pathway is widely used in cancer treatment. My present study focuses on assessing the risk of space radiation on the central nervous system and develop space radiation protection strategies utilizing a label-free and real-time 3D human neurovascular unit for high throughput screening radiation countermeasure compounds. .Complete List of Published Work in MyBibliography: I have more than 50 peer reviewed published papers, article reviews and book chapters. https://www.ncbi.nlm.nih.gov/myncbi/1ZGFs6JOGMh/bibliography/public/. https://scholar.google.com/citations?user=nrD5FloAAAAJ&hl=en