Karima Addetia, MD, FRCPC is a Cardiologist with level III training in Echocardiography and Cardiovascular MRI who is currently Junior Faculty at the University of Chicago, Section of Cardiology, Chicago, IL, USA. She obtained her medical degree at Memorial University of Newfoundland in Newfoundland, Canada in the year 2001. She completed her Internal Medicine residency and fellowships also at Memorial University of Newfoundland in 2005. She subsequently went on to complete both Cardiology and Echocardiography fellowships at McGill Univeristy in Montreal, Quebec, Canada in 2011. She then worked as a Cardiologist for a year in Montreal before moving to Chicago to complete a fellowship in advanced cardiac imaging and research in 2014. During these two years she completed a fellowship in cardiovascular MRI and obtained advanced training in 3D echocardiography. Her research interests include the right ventricle, the tricuspid valve and using echocardiographic and cardiovascular-based tools to assess patient outcomes and response to therapies. This challenge is submitted on behalf of the University of Chicago and Epsilon Imaging. Most recent publications include: 1: Addetia K, Takeuchi M, Maffessanti F, Nagata Y, Hamilton J, Mor-Avi V, Lang RM. Simultaneous Longitudinal Strain in All 4 Cardiac Chambers: A Novel Method for Comprehensive Functional Assessment of the Heart. Circ Cardiovasc Imaging. 2016 Mar;9(3):e003895. doi: 10.1161/CIRCIMAGING.115.003895. PubMed PMID: 26926268. 2: Uriel N, Sayer G, Addetia K, Fedson S, Kim GH, Rodgers D, Kruse E, Collins K, Adatya S, Sarswat N, Jorde UP, Juricek C, Ota T, Jeevanandam V, Burkhoff D, Lang RM. Hemodynamic Ramp Tests in Patients With Left Ventricular Assist Devices. JACC Heart Fail. 2016 Mar;4(3):208-17. doi: 10.1016/j.jchf.2015.10.001. Epub 2015 Dec 30. PubMed PMID: 26746378. 3: Medvedofsky D, Aronson D, Gomberg-Maitland M, Thomeas V, Rich S, Spencer K, Mor-Avi V, Addetia K, Lang RM, Shiran A. Tricuspid regurgitation progression and regression in pulmonary arterial hypertension: implications for right ventricular and tricuspid valve apparatus geometry and patients outcome. Eur Heart J Cardiovasc Imaging. 2016 Feb 11. pii: jew010. [Epub ahead of print] PubMed PMID: 26873457. 4: Murtagh G, Laffin LJ, Beshai JF, Maffessanti F, Bonham CA, Patel AV, Yu Z, Addetia K, Mor-Avi V, Moss JD, Hogarth DK, Sweiss NJ, Lang RM, Patel AR. Prognosis of Myocardial Damage in Sarcoidosis Patients With Preserved Left Ventricular Ejection Fraction: Risk Stratification Using Cardiovascular Magnetic Resonance. Circ Cardiovasc Imaging. 2016 Jan;9(1):e003738. doi: 10.1161/CIRCIMAGING.115.003738. PubMed PMID: 26763280; PubMed Central PMCID: PMC4718184. 5: Mizukoshi K, Takeuchi M, Nagata Y, Addetia K, Lang RM, Akashi YJ, Otsuji Y. Normal Values of Left Ventricular Mass Index Assessed by Transthoracic Three-Dimensional Echocardiography. J Am Soc Echocardiogr. 2016 Jan;29(1):51-61. doi: 10.1016/j.echo.2015.09.009. Epub 2015 Oct 23. PubMed PMID: 26601701. 6: Addetia K, Yamat M, Mediratta A, Medvedofsky D, Patel M, Ferrara P, Mor-Avi V, Lang RM. Comprehensive Two-Dimensional Interrogation of the Tricuspid Valve Using Knowledge Derived from Three-Dimensional Echocardiography. J Am Soc Echocardiogr. 2016 Jan;29(1):74-82. doi: 10.1016/j.echo.2015.08.017. Epub 2015 Sep 28. PubMed PMID: 26427537. 7: Altmayer SP, Patel AR, Addetia K, Gomberg-Maitland M, Forfia PR, Han Y. Cardiac MRI right ventricle / left ventricle (RV/LV) volume ratio improves detection of RV enlargement. J Magn Reson Imaging. 2015 Dec 9. doi: 10.1002/jmri.25110. [Epub ahead of print] PubMed PMID: 26646199. 8: Medvedofsky D, Addetia K, Patel AR, Sedlmeier A, Baumann R, Mor-Avi V, Lang RM. Novel Approach to Three-Dimensional Echocardiographic Quantification of Right Ventricular Volumes and Function from Focused Views. J Am Soc Echocardiogr. 2015 Oct;28(10):1222-31. doi: 10.1016/j.echo.2015.06.013. Epub 2015 Aug 1. PubMed PMID: 26237996. 8: Medvedofsky D, Addetia K, Hamilton J, Leon Jimenez J, Lang RM, Mor-Avi V. Semi-automated echocardiographic quantification of right ventricular size and function. Int J Cardiovasc Imaging. 2015 Aug;31(6):1149-57. doi: 10.1007/s10554-015-0672-4. Epub 2015 May 7. PubMed PMID: 25948160. 9: Addetia K, Maffessanti F, Yamat M, Weinert L, Narang A, Freed BH, Mor-Avi V, Lang RM. Three-dimensional echocardiography-based analysis of right ventricular shape in pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2015 Jul 9. pii: jev171. [Epub ahead of print] PubMed PMID: 26160404. 10: Addetia K, Michel C, Holcroft CA, Sheppard R, Rudski LG. Early improvement in serial echocardiographic studies in heart failure patients predicts long term survival-a pilot study. J Card Fail. 2015 Jun;21(6):470-8. doi: 10.1016/j.cardfail.2015.04.002. Epub 2015 Apr 14. PubMed PMID: 25887445. 11: Addetia K, Maffessanti F, Mediratta A, Yamat M, Weinert L, Moss JD, Nayak HM, Burke MC, Patel AR, Kruse E, Jeevanandam V, Mor-Avi V, Lang RM. Impact of implantable transvenous device lead location on severity of tricuspid regurgitation. J Am Soc Echocardiogr. 2014 Nov;27(11):1164-75. doi: 10.1016/j.echo.2014.07.004. Epub 2014 Aug 14. PubMed PMID: 25129393; PubMed Central PMCID: PMC4455541. 12: Cain MA, Metzl MD, Patel AR, Addetia K, Spencer KT, Sweiss NJ, Beshai JF. Cardiac sarcoidosis detected by late gadolinium enhancement and prevalence of atrial arrhythmias. Am J Cardiol. 2014 May 1;113(9):1556-60. doi: 10.1016/j.amjcard.2014.01.434. Epub 2014 Feb 12. PubMed PMID: 24731652. 13: Mediratta A, Addetia K, Yamat M, Moss JD, Nayak HM, Burke MC, Weinert L, Maffessanti F, Jeevanandam V, Mor-Avi V, Lang RM. 3D echocardiographic location of implantable device leads and mechanism of associated tricuspid regurgitation. JACC Cardiovasc Imaging. 2014 Apr;7(4):337-47. doi: 10.1016/j.jcmg.2013.11.007. Epub 2014 Mar 13. PubMed PMID: 24631508. 14: Addetia K, Bhave NM, Tabit CE, Gomberg-Maitland M, Freed BH, Dill KE, Lang RM, Mor-Avi V, Patel AR. Sample size and cost analysis for pulmonary arterial hypertension drug trials using various imaging modalities to assess right ventricular size and function end points. Circ Cardiovasc Imaging. 2014 Jan;7(1):115-24. doi: 10.1161/CIRCIMAGING.113.000932. Epub 2013 Nov 5. PubMed PMID: 24192452. 15: Addetia K, Mor-Avi V, Weinert L, Salgo IS, Lang RM. A new definition for an old entity: improved definition of mitral valve prolapse using three-dimensional echocardiography and color-coded parametric models. J Am Soc Echocardiogr. 2014 Jan;27(1):8-16. doi: 10.1016/j.echo.2013.08.025. Epub 2013 Oct 2. PubMed PMID: 24094553.