NIH has selected the following Phase 1 winners to share in the $7 million prize pool of the Complement-ARIE NAMs Reduction to Practice Challenge. The winners are:

  • Predictive Brain Combinatorial NAM, submitted by Massachusetts General Hospital
  • Combining vTIME and AI for IO Drug CRS Prediction, submitted by Qureator Inc.
  • Human Lung Models for Anti-Fibrotic Drug Testing, submitted by Wake Forest University Health Sciences
  • Combinatorial NAM for Human Atherosclerosis Model, submitted by Endomimetics Inc.
  • CAR-T Immunotherapy Clinical Trials on a Chip, submitted by CAR-T Chips Team
  • AI-integrated human skin immune organoids, submitted by Stanford University
  • Combinatorial Human Bone Remodeling NAM Platform, submitted by University of Massachusetts - Amherst
  • PACE-IT: Immune-Cardiac NAM for Med Device Testing, submitted by University of Minnesota
  • High-Throughput Human Tissue Remodeling & Toxicity, submitted by First State Click-Chem Solutions
  • Combinatorial NAM for Endometriosis Drug Efficacy, submitted by VeriSIM Life, Inc.
  • Multi-Brain Region Assembloid Combinatorial Models, submitted by Regenerative Research Foundation
  • Multiorgan Predictive Biologic Toxicity Framework, submitted by Biopico Systems Inc.
  • Human Brain Organoids to Predict DNT, submitted by Bioprinting Laboratories Inc.
  • Precision dosing of oligonucleotide therapeutics, submitted by Javelin Biotech Inc.
  • NeuroTraX-AI, submitted by Frontier Bio Corporation
  • AI-Driven Antibody Repurposing for New Therapies, submitted by Wake Forest University Health Sciences
  • LIVER-COMBINE: A Human Relevant NAM Platform, submitted by Liver-Combine Consortium
  • Gut Feelings: A GI Toxicity Prediction Engine, submitted by Cedars-Sinai Medical Center
  • Plasticity Biomarkers in Human Cortical Organoids, submitted by 28bio Inc.
  • MAJIC: The Future of Human Joint Drug Testing, submitted by CellField Technologies Inc. 

In Phase 2, solvers must complete Milestone 1) by demonstrating progress developing their combinatorial NAM platform according to fit-for-purpose needs. Solvers must also demonstrate clear progress in initial performance testing. Up to 10 winners will receive $150,000 per winner upon completion of Milestone 1. In Milestone 2) solvers must demonstrate progress toward internal validation and reproducibility of results generated by the NAM platform against reference standards or their equivalent, submit data that meets standards of the Complement-ARIE NAMs Data Hub and Coordination Center (NDHCC), and document how the NAM platform can be assessed by the VQN. These standards will be based on established principles (findable, accessible, interoperable, and reusable (FAIR), technological readiness levels, etc.) and will be more clearly defined by the NDHCC and VQN as the challenge progresses. Up to 7 winners will receive $200,000 per winner upon completion of Milestone 2.

 

Congratulations once again to our winners!